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. 2014 Sep 4;12:245. doi: 10.1186/s12967-014-0245-7

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© Fisher et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Enhanced CD8 T cell activation following CD4 Depletion. Flow cytometry analysis of pre (baseline) and post-treatment (day 22) peripheral blood lymphocytes taken from the same mice shown in Figure 2B. (A-B) The relative proportion and activation (ICOS) status of CD4, CD8 and Treg (CD4 + FoxP3+) lymphocyte subsets were similar between all groups prior to treatment. (C-D) CD4 T cell depletion resulted in a significant increase (****p < 0.0001) in the relative proportion and activation status of CD8 T cells (black squares) compared to the respective non-CD4 depleted groups.