Table 5.

Summary of the top ten pathways returned by REACTOME using CPDB for early- and late-stage NSCLC.

Early-stage NSCLC
Pathway name	Effective size	% of overlap	P value
Cell surface interactions at the vascular wall	94	6.4%	1.53E − 08
Nephrin interactions	23	13%	1.02E − 05
Hemostasis	463	1.5%	1.45E − 05
Glycolysis	28	10.7%	1.87E − 05
Gluconeogenesis	32	9.4%	2.82E − 05
PECAM1 interactions	12	16.7%	0.00022
Integrin cell surface interactions	66	4.5%	0.00025
Glucose metabolism	67	4.5%	0.00026
Regulation of signaling by CBL	18	11.1%	0.00052
CD28 dependent PI3K/Akt signaling	21	9.5%	0.00071
Late-stage NSCLC
Pathway name	Effective size	% of overlap	P value
Cell cycle	442	5.9%	5.15E − 21
Cell cycle, mitotic	355	6.8%	1.02E − 20
Mitotic M-M/G1 phases	214	8.4%	3.88E − 17
APC/C-mediated degradation of cell cycle proteins	38	26.3%	4.87E − 15
Regulation of mitotic cell cycle	38	26.3%	4.87E − 15
M phase	183	8.2%	3.57E − 14
Mitotic prometaphase	110	10.9%	5.59E − 13
Mitotic anaphase	130	9.2%	4.22E − 12
Mitotic metaphase and anaphase	131	9.2%	4.63E − 12
Resolution of sister chromatid cohesion	101	10.9%	5.80E − 12