FIG. 3.

Granulocyte CR3 upregulation and oxidative burst by LPS⁺ and LPS⁻ N. meningitidis and by purified NmLPS. The results are for CR3 (CD11b/CD18) upregulation and oxidative burst in human granulocytes after the stimulation of lepirudin-treated human whole blood for 10 min with LPS⁺ (diamonds) or LPS⁻ (squares) N. meningitidis or purified NmLPS (circles). The x axes are calibrated for the numbers of LPS⁺ N. meningitidis cells as well as the amounts of NmLPS that are present in the bacteria, according to SDS-PAGE analysis. One representative of three separately performed experiments is shown. Dashed lines indicate baseline CR3 expression or oxidative burst.