Table 3.
Determination of ascorbic acid in ascorbic acid tablet and ascorbic acid injection solution using the procedure.
| Sample |
Proposed method
|
RSD
(%) |
AOAC
|
RSD (%) |
Labled
(mg/tablet) |
Statistical test
|
Pharmaceutical Co./
Batch No. |
|
|---|---|---|---|---|---|---|---|---|
| Found a (mg/tablet) | Found a (mg/tablet) | t-test b | F-test c | |||||
|
Ascorbic acid
tablet |
||||||||
| 1 | 248.1 ± 2.1 | 0.85 | 246.7 ± 1.9 | 0.77 | 250 | 1.33 | 1.22 | Osvah-Iran/438 |
| 2 | 248.1 ± 2.0 | 0.80 | 247.3 ± 1.8 | 0.73 | 250 | 0.80 | 1.23 | |
| 1 | 243.4 ± 1.8 | 0.74 | 242.2 ± 1.9 | 0.78 | 250 | 1.33 | 1.11 | Osvah-Iran/439 |
| 2 | 244.9 ± 1.9 | 0.77 | 246.1 ± 2.0 | 0.81 | 250 | 1.26 | 1.11 | |
|
Ascorbic acid
injection solution |
||||||||
| 1 | 495.5 ± 4.3 | 0.87 | 494.5 ± 5.3 | 1.07 | 500 | 0.46 | 1.52 | Daru Pakhsh-Iran/778 |
| 2 | 482.4 ± 4.5 | 0.93 | 484.0 ± 4.2 | 0.87 | 500 | 0.71 | 1.15 | |
| 1 | 493.1 ± 6.2 | 1.26 | 495.1 ± 5.6 | 1.13 | 500 | 0.64 | 1.22 | Daru Pakhsh-Iran/781 |
| 2 | 491.0 ± 5.0 | 1.02 | 488.3 ± 4.5 | 0.92 | 500 | 1.26 | 1.23 | |
a
Mean ± standard deviation (n=4)
b
Tabulated t-value for three degrees of freedom at P(0.95) is 3.18.
c
Tabulated F-value for three degrees of freedom at P(0.95) is 9.28.