FIG. 1.

Kinetics of HuIgM concentrations in the plasma of the HEL- and protein L-treated transgenic mice on days 1, 3, 5, 7, and 9. HuIgM concentrations were measured in the plasma of individual mice. (A) Total human IgM concentrations show no significant variations between the two groups. (B) Protein L⁺ HuIgM concentrations exhibit a dramatic specific decrease in the protein L-injected mice but not in the HEL-treated mice. ✽, P < 0.05; ✽✽, P < 0.005.