Table 2.
Phase II anticonvulsant evaluation in micea.
| Compound | ED 50 (MES)b | ED 50 (PTZ)c | TD 50 d |
PI
(TD50/ ED50) |
|
|---|---|---|---|---|---|
| MES | PTZ | ||||
| 3c | 49.1 (44.4-54.3) | - | 94.7 (86.1-104.2) | 1.9 | - |
| 5b | -e | 63.4 (55.0-73.1) | 105.6 (92.4-120.7) | - | 1.7 |
| Carbamazepine | 9.8 (8.9-10.8) | >100 | 44.0 (40.2-48.1) | 4.5 | <0.44 |
a
: All animals was administered intraperitoneal injection.
b
: The median effective dose (ED50) was measured in maximal electroshock seizure test, confidence intervals given in the bracket and the unit is mg/Kg.
c
: The median effective dose (ED50) was measured in pentylenetetrazole-induced seizure test, confidence intervals given in the bracket and the unit is mg/Kg.
d
: The median neurotoxic dose (TD50) was measured in the rotarod test, confidence intervals given in the bracket and the unit is mg/Kg.
e
: Not tested.