Table 1.

Heart function parameters of rats in all groups

	Sham	Vehicle	MP	DOX
Group size	27	22	20	22
HR (bpm)	311 ± 18	304 ± 15	297 ± 14	302 ± 16
LVDd (mm)	4.88 ± 0.63	6.54 ± 0.67*	6.61 ± 0.83*	5.38 ± 0.43‡§
LVSd (mm)	3.05 ± 0.55	5.01 ± 0.58*	5.20 ± 0.91*	3.75 ± 0.57‡§
FS (%)	36 ± 2.50	23 ± 4.18*	22 ± 5.65*	31 ± 6.31§
EF (%)	73 ± 9.2	47 ± 6.6*	43 ± 7.3*	56 ± 5.8*‡§

MP = methylprednisolone, DOX = doxycycline, HR = heart rate, LVSd = Left ventricular end-systolic diameter, LVEDd = Left ventricular end-diastolic diameter, FS = Left ventricular fractional shortening, EF= Left ventricular ejection fraction.

^*vs. sham group p<0.05,

^‡vs. vehicle group p<0.05,

^§vs. MP group p<0.05.