Figure 1.

The effect of different doses of RO25-6981 compared to PBS and memantine on changes in mean body weight over time during EAE. All groups (except sham group) showed similar progression of weight loss till day 12, but groups treated with RO 25-6981, specially group 5 (25 mg/Kg/day) displayed gradual recovery of weight from day 12 p.i. EAE+Ro 25= EAE groups treated with RO 25-6981 ( Groups 3,4 and 5), EAE+ Memantine= EAE group treated with Memantine (group 2). Each graph presents daily mean body weight ± S.E.M. = Significant compared to PBS