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. 2014 Spring;13(2):695–705.

Figure 2.

Figure 2

The effect of different doses of RO25-6981 compared to PBS and memantine on changes in daily mean neurological scores over time during EAE. Low dose of Ro 25-6981 (3 mg/Kg/day; group 3) showed no improvement in the course of EAE, but moderate dose (10 mg/Kg/day; group 4) displayed a modest improvement compared to PBS (group 1). Subsequent increase in dose to 25 mg/Kg/day (group 5) demonstrated superior efficacy of RO 25-6981 compared to memantine. EAE+Ro 25= EAE groups treated with RO 25-6981 (Groups 3, 4 and 5), EAE+ Memantine= EAE group treated with Memantine (group 2). Each graph presents daily mean neurological score± S.E.M.  = Significant compared to PBS (Phosphate Buffer Saline) and memantine. EAE= Experimental Autoimmune Encephalomyelitis, SEM=standard error of means, Ro= RO 25-6981.