TABLE 2.
Phenotypic characteristics of strains recovered from the brainc
| Strain | Doubling time (h) | Capsule thickness (μm)b | MIC of drug for straina
|
Capsule structure
|
|||
|---|---|---|---|---|---|---|---|
| ITZ | FCZ | AmB | Fluorescence intensity (MdF) | Heterogeneity of cell population (CVF) | |||
| B.1.1 | 5.0 | 0.17 ± 0.05 | 0.5 | 8 | 1 | 1.2 | 202 |
| B.1.2 | 4.2 | 0.20 ± 0.10 | 0.5 | 8 | 0.5 | 31.7 | 203 |
| B.1.3 | 4.1 | 0.16 ± 0.06 | 0.25 | 8 | 0.5 | 79.6 | 144 |
| B.1.4 | 3.9 | 0.16 ± 0.05 | 0.5 | 4 | 0.5 | 9.7 | 227 |
| B.1.5 | 3.7 | 0.23 ± 0.09 | 0.125 | 4 | 0.5 | 70.2 | 163 |
| B.8.1 | 4.0 | 0.20 ± 0.08 | 0.5 | 8 | 1 | 34.4 | 200 |
| B.8.2 | 4.1 | 0.17 ± 0.05 | 0.25 | 8 | 0.5 | 86.4 | 143 |
| B.8.3 | 4.1 | 0.20 ± 0.06 | 0.125 | 8 | 0.5 | 13.3 | 247 |
| B.8.4 | 3.7 | 0.17 ± 0.06 | 0.25 | 8 | 0.5 | 17.4 | 209 |
| B.8.5 | 4.2 | 0.19 ± 0.05 | 0.06 | 4 | 0.5 | 43.7 | 162 |
| B.35.1 | 6.1 | 0.17 ± 0.04 | 0.03 | 4 | 0.5 | 5.4 | 250 |
| B.35.2 | 6.6 | 0.16 ± 0.05 | 0.03 | 2 | 0.5 | 8.7 | 235 |
| B.35.3 | 7.1 | 0.16 ± 0.06 | 0.03 | 4 | 0.5 | 7.0 | 232 |
| B.35.4 | 3.9 | 0.23 ± 0.06 | 0.125 | 8 | 0.5 | 14.7 | 224 |
| B.35.5 | 19.6 | 0.17 ± 0.05 | 0.015 | 2 | 0.25 | 8.0 | 249 |
a
ITZ, itraconazole; FCZ, fluconazole; AmB, amphotericin B.
b
Data are means ± SD.
c
Different phenotypes of strains recovered from the brain on day 1 (B.1.X), day 8 (B.8.X), and day 35 (B.35.X) were studied.