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MyD88−/− mice exhibit a shift toward Th2-associated B. burgdorferi-specific antibody isotype responses. B. burgdorferi-specific antibody titers in the sera of WT and MyD88−/− mice infected for 14 days (A) or 28 days (B) were measured by isotype-specific ELISA. *, the value for MyD88−/− mouse sera differed significantly from the WT value for the indicated antibody class and isotype (P value range, 0.0007 to 0.05, by the Mann-Whitney test).
