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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: J Immunol. 2014 Aug 4;193(6):2733–2742. doi: 10.4049/jimmunol.1401039

Figure 2. Type I IFNs directly inhibit Treg cell proliferation and activation in Trex1−/− mice.

Figure 2

Summary of Ki-67 (a), CXCR3 (b), CD44 (c), and CD69 (d) expression by CD45.2+CD4+Foxp3+ Treg cells in the IEL (left) and LPL (right) in the colons of Rag2−/−Trex1−/− mice receiving the indicated combinations of CD45.2+ WT or Ifnar1−/− (knockout, “KO”) Treg and CD45.1+ TNaive cells. Data are summarized from 8 independent experiments with 3–4 mice per group. Statistical significance was determined using one- way ANOVA with Tukey post-test. *, p<0.05; **, p<0.005; ***, p<0.0001.