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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: J Immunol. 2014 Aug 4;193(6):2919–2930. doi: 10.4049/jimmunol.1400980

Figure 4. Modulatory effects of IL-2-anti-IL-2 complex treatment on SEB-induced expansion of peripheral T cells and deletion of thymocytes in HLA-DR3 transgenic mice.

Figure 4

HLA-DR3 transgenic mice were left untreated or injected with immune complexes comprising of IL-2 and anti-IL-2 on days 0, 1 and 2 (3xIL2C). On day 5, mice were challenged with SEB (50 µg/mouse) or PBS and killed 3 days later for flow cytometric analysis. (A) Distribution of CD4+ and CD8+ T cells expressing TCR Vβ8 (SEB-responsive) and TCR Vβ6 (SEB non-responsive) in the spleens and (B) Thymus. Each bar represents mean±SE of data obtained from 6–8 mice in each group. * p<0.05 compared to naïve mice. # p<0.05 compared to SEB group.