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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: J Immunol. 2014 Aug 4;193(6):2919–2930. doi: 10.4049/jimmunol.1400980

Figure 5. Organ pathology during SEB-induced toxic shock syndrome in HLA-DR3 transgenic mice and its modulation by IL-2-anti-IL-2 complexes.

Figure 5

HLA-DR3 transgenic mice were left untreated or injected with IL-2, anti-IL-2 immune complexes on days 0, 1 and 2 (3xIL2C) to expand endogenous Tregs. On day 5, mice were challenged with SEB (50 µg/mouse) or PBS and killed 3 days later. Organs were collected in buffered formalin, paraffin-embedded and processed. Hematoxylin and Eosin stained sections were evaluated by light microscopy. Representative low and high magnification images are shown.