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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Mol Immunol. 2014 Jun 28;62(1):96–103. doi: 10.1016/j.molimm.2014.06.013

Figure 3.

Figure 3

LIGHT-enhanced CXCL10 production in response to IFN-γ stimulation is primarily mediated by signaling through LTβR. A. Soluble LIGHT synergizes with IFN-γ to promote CXCL10 production by both HeLa and HT-29 cells. B. Mutant forms of membrane-bound LIGHT which interact preferentially with HVEM (G119E) or LTβR (R228E) suggest that the majority of LIGHT-induced signaling is through LTβR in both cell types. Experiments were done with triplicate samples twice, with representative data shown.