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B cells proliferate in response to r27. (A) B or T cells were purified from BALB/c splenocytes and stimulated with r27 (10 μg/ml) for 24 h; then [3H]thymidine was added for an additional 16 h. **, P < 0.001 (compared to B cells). (B) IFN-γ levels were measured after 48 h of stimulation with r27 in whole BALB/c splenocytes, purified B or T cells, and whole nu/nu splenocytes. *, P < 0.01 (compared to stimulation with r27ΔSP).
