FIG. 1.

Infection of AGS cells with H. pylori results in two early cellular phenotypes: the stimulation of migratory behavior and dramatic elongation of the host cells. (A) Single AGS cell colonies were investigated in a time course during infection with wild-type strain P12 by time-lapse phase-contrast microscopy as indicated. Cells shown are numbered 1 to 4. Arrows indicate those cells with significant elongation. (B) Investigation of the migratory behavior and dramatic elongation of a single AGS cell infected with H. pylori strain P1. The AGS cell marked by the arrows expresses a transfected actin-enhanced green fluorescent protein construct to monitor actin cytoskeletal rearrangements over 650 min of infection.