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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Leuk Res. 2014 May 21;38(9):1091–1096. doi: 10.1016/j.leukres.2014.05.004

Table 2.

Conventional cytogenetics, FISH, and SNP-array findings in cases of MS without blood or bone marrow involvement.

Case CC-Mass CC-BM FISH Molecular Studies CMA results
1 46,XX,inv(16)(p13.1q2 2)[7]/47,idem,+22[7]/4 6,XX[7] ND ND ND CN-LOH 6p25.3-p21.32 Gain of chr22
2 47,XX,+8[20] ND +8 FLT3 D835 mutation positive Gain of chr8 CN-LOH chr13
3 Inadequate 46,XX[20] Negative for t(8;21)-RUNX1/RUNX1T1 and inv(16)-CBFB NPM1, FLT3-ITD mutation positive CN-LOH chr13
4 ND ND Negative for t(8;21)-RUNX1/RUNX1T1 and inv(16)-CBFB Negative for NPM1, FLT3 BCR/ABL1 CN-LOH 11pter-p11.2
5 ND 46,XY[20] Negative for t(8;21)-RUNX1/RUNX1T1, 11(q23)-MLL, inv(16)-CBFB; positive for +19 Negative for NPM1, FLT3 mutations Gain of chr7, chr19 Loss 1p36.33-p36.22, 6q27, 13q12.3-q31.1
6 ND ND ND Negative for NPM1, FLT3 mutations Loss 1p21.1-p12, 1q23.1-q23.3, 15q11.2-q14 Gain 1q21.1-q23.1, 1q23.3-q44, 2q12.1-q36.3, 16pter-p11.1, 19p13.3-p11 Gain chr12, Loss chr13 CN-LOH 8q21.11-q24.11

ND-not determined