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Extracellular neutralization. (a) Sera neutralize tissue culture adapted (TCLA) SIVmac 251, at 20 weeks at higher titer compared to 5 weeks. (b, c) Compared to pre-bleed sera, SIVmac251-32H and the challenge stock of WT SIVmac251 are partially neutralized over a broad range of dilutions, to 50% reduction in infectivity with 20-week sera.
