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Smoking over 5 pack years increases significantly the chance of failure (OR = 1.659 in smokers 5–10 pack year and OR = 2.395 in the group smoking over 10 pack years) compared to non-smokers.
| Pack year | OR | 95% CI | P |
|---|---|---|---|
| Non smokers | 1 | ||
| x ≤ 1 | 1.028 | [0.602–1.757] | 0.918 |
| 1 < x ≤ 5 | 1.227 | [0.812–1.853] | 0.331 |
| 5 < x ≤ 10 | 1.659 | [1.172–2.349] | 0.004 |
| x > 10 | 2.395 | [1.741–3.294] | <0.0014 |
