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. 2004 Jun;72(6):3471–3477. doi: 10.1128/IAI.72.6.3471-3477.2004

FIG. 2.

FIG. 2.

Anti-PA Ab avidity measured after primary and secondary immunization. Guinea pigs were immunized with a PA-based vaccine and boosted with the same PA dose 2 months after the first immunization. The anti-PA avidities of individual serum samples were determined 14 days after the first immunization and 14 days after the booster. Relative avidities are expressed as percentages of ELISA optical density values in the absence and presence of 1.5 M thiocyanate. (A) Primary and booster immunizations with 25 μg of PA. (B) Primary and booster immunizations with 1 μg of PA. The anti-PA Ab levels (GMT) in animals immunized with 25 μg of PA were 12,800 after primary vaccination and 25,600 after booster vaccination. In animals vaccinated with 1 μg of PA, a titer of 18,000 was reached after booster vaccination. *, no Ab titers were measured during primary immunization with 1 μg of PA.