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Structural comparison of Msm Eis complexed with paromomycin only and Mtb Eis complexed with both CoA and tobramycin (binding mode A; Houghton et al., 2013 ▶). (a) Monomers of paromomycin-bound Msm Eis (gray) and CoA/tobramycin-bound Mtb Eis (yellow) are superimposed. (b) Close-up view of the aminoglycoside-binding pocket, as indicated by a red rectangle in (a). Paromomycin (cyan) and tobramycin (salmon) are shown as stick models.
