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. 2014 Aug 29;70(Pt 9):2477–2486. doi: 10.1107/S139900471401606X

Figure 4.

Figure 4

The putative substrate-recognition site of PvuRts1I. Comparison of the SRA-like domain structure of PvuRts1I (green) with the SRA-domain structure of (a) human UHRF1 (PDB entry 3clz, pink; Avvakumov et al., 2008 ▶) and (b) Arabidopsis SUVH5 (PDB entry 3q0f, yellow; Rajakumara et al., 2011 ▶) in complex with substrate DNA. The NKR finger and thumb loop are coloured red and indicated by arrows. A detailed view of the putative 5-hmC binding pocket superimposed on the 5-mC binding pocket of (c) human UHRF1 and (d) Arabidopsis SUVH5. The amino-acid residues and 5-mC are shown in stick representation. (e) Surface representation of the SRA-like domain of PvuRts1I. Amino-acid residues proposed to be involved in 5-hmC recognition are labelled.