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Improving the substrate selectivity of PvuRts1I via point mutations (see §2 for a description of the methods used). (a) Detailed view of the SRA-like domain of PvuRts1I. Amino acids potentially involved in the recognition of 5-hmC are shown in stick mode. (b) Endonuclease activity of PvuRts1I and its mutants towards C (cytosine; upper panel), 5-mC (5-methylcytosine; middle panel) and 5-hmC (5-hydroxymethylcytosine; bottom panel).
