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. 2014 Sep 8;5:430. doi: 10.3389/fimmu.2014.00430

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Copyright © 2014 Beljaars, Schippers, Reker-Smit, Martinez, Helming, Poelstra and Melgert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression and localization of macrophages in normal and cirrhotic human livers. Immunohistochemical analysis shows enhanced deposition of the extracellular matrix protein collagen type I (A,B) and presence of macrophages [CD68 (C–F)] in normal (C) cirrhotic livers of various origins [(D) PBC (E) PSC and (F) congenital cirrhosis]. Note the abundant presence of macrophages in the collagenous fibrotic bands (F). (G,H) Image analysis of CD68 staining in human livers. Reduced CD68 staining was found in the parenchymal area (p) of human cirrhotic livers as compared to normal. Magnifications: 40× (A,B) and 100× (C–F). f, fibrotic matrix; p, liver parenchyma. N = 5 cirrhotic livers, N = 6 normal livers.