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. 2014 Sep 8;5:430. doi: 10.3389/fimmu.2014.00430

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Copyright © 2014 Beljaars, Schippers, Reker-Smit, Martinez, Helming, Poelstra and Melgert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Localization of IRF-5 (M1) in mouse and human livers. (A) Co-localization of IRF-5 and CD68 in mouse and human livers. (B) Double-staining for IRF-5 (blue staining) and CD206 (red staining) showed no co-localization. (C,D) Immunohistochemical staining of IRF-5 in normal mice livers (C) and in livers after chronic CCl4 damage (D). (E,F) IRF-5 staining of normal (E) and cirrhotic (F) human livers. f, fibrotic matrix. Magnifications: 100× (C–F) and 400× (A,B). N = 5 cirrhotic human livers, N = 6 normal human livers, N = 4 normal mouse livers, N = 6 fibrotic mouse livers.