Table 2.
Crude and adjusted odds ratios (95% confidence interval) for having thrombosis within 30 days after intervention according to presence of sepsis before surgery
| Any sepsis (n=167 986) | Sepsis severity | |||
|---|---|---|---|---|
| SIRS* (n=103 479) | Sepsis† (n=48 735) | Severe sepsis‡ (n=15 772) | ||
| Composite endpoint for arterial or venous thromboses | ||||
| No (%) | 7018 (4.2) | 3272 (3.2) | 2220 (4.6) | 1526 (9.7) |
| Crude odds ratio | 3.5 (3.4 to 3.5) | 2.6 (2.5 to 2.7) | 3.8 (3.6 to 4.0) | 8.5 (8.0 to 9.0) |
| Adjusted odds ratio§ | 3.1 (3.0 to 3.1) | 2.5 (2.4 to 2.6) | 3.3 (3.1 to 3.4) | 5.7 (5.4 to 6.1) |
| Arterial thrombosis | ||||
| No (%) | 2632 (1.6) | 1247 (1.2) | 771 (1.6) | 614 (3.9) |
| Crude odds ratio | 3.2 (3.0 to 3.3) | 2.4 (2.3 to 2.6) | 3.2 (3.0 to 3.5) | 8.1 (7.5 to 8.8) |
| Adjusted odds ratio§ | 2.7 (2.5 to 2.8) | 2.2 (2.1 to 2.4) | 2.6 (2.4 to 2.8) | 5.0 (4.6 to 5.4) |
| Myocardial infarction | ||||
| No (%) | 1643 (1.0) | 746 (0.7) | 545 (1.1) | 352 (2.2) |
| Crude odds ratio | 3.3 (3.1 to 3.5) | 2.4 (2.2 to 2.6) | 3.8 (3.5 to 4.1) | 7.6 (6.8 to 8.5) |
| Adjusted odds ratio§ | 2.6 (2.5 to 2.8) | 2.1 (2.0 to 2.3) | 2.9 (2.6 to 3.1) | 4.1 (3.7 to 4.6) |
| Stroke | ||||
| No (%) | 1056 (0.6) | 536 (0.5) | 244 (0.5) | 276 (1.8) |
| Crude odds ratio | 3.0 (2.8 to 3.3) | 2.5 (2.3 to 2.7) | 2.4 (2.1 to 2.8) | 8.6 (7.6 to 9.7) |
| Adjusted odds ratio§ | 2.7 (2.5 to 2.9) | 2.4 (2.2 to 2.6) | 2.1 (1.9 to 2.4) | 6.1 (5.3 to 6.9) |
| Venous thrombosis | ||||
| No (%) | 4590 (2.7) | 2121 (2.1) | 1509 (3.1) | 960 (6.1) |
| Crude odds ratio | 3.6 (3.5 to 3.7) | 2.7 (2.6 to 2.8) | 4.1 (3.9 to 4.3) | 8.3 (7.7 to 8.8) |
| Adjusted odds ratio§ | 3.3 (3.2 to 3.4) | 2.6 (2.5 to 2.7) | 3.7 (3.5 to 3.9) | 6.1 (5.7 to 6.5) |
| Pulmonary embolism | ||||
| No (%) | 1208 (0.7) | 657 (0.6) | 377 (0.8) | 174 (1.1) |
| Crude odds ratio | 2.4 (2.2 to 2.6) | 2.1 (2.0 to 2.3) | 2.6 (2.4 to 2.9) | 3.8 (3.2 to 4.4) |
| Adjusted odds ratio§ | 2.4 (2.3 to 2.6) | 2.2 (2.0 to 2.4) | 2.6 (2.3 to 2.9) | 3.1 (2.6 to 3.6) |
| Deep venous thrombosis | ||||
| No (%) | 3719 (2.2) | 1641 (1.6) | 1237 (2.5) | 841 (5.3) |
| Crude odds ratio | 4.1 (3.9 to 4.2) | 2.9 (2.8 to 3.1) | 4.7 (4.4 to 5.0) | 10.2 (9.5 to 11.0) |
| Adjusted odds ratio§ | 3.7 (3.5 to 3.8) | 2.8 (2.7 to 3.0) | 4.2 (3.9 to 4.4) | 7.2 (6.7 to 7.8) |
SIRS=systemic inflammatory response syndrome.
*Defined by presence of two or more of: body temperature >38°C or <36°C; heart rate >90 beats/min; respiratory rate >20 breaths/min or PaCO2 <32 mm Hg; white blood cells >12<thin>000 cell/mm3, <4000 cells/mm3, or >10% immature (band) forms; anion gap acidosis.
†SIRS plus one of: positive result on blood culture; clinical documentation of purulence or positive culture from any site thought to be causative.
‡Sepsis and documented organ and/or circulatory dysfunction.
§Adjusted for age, sex, diabetes, smoking status, treated arterial hypertension, renal failure, cancer, bleeding disorder or anticoagulation, general anesthesia, surgical subspecialty.