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. 2014 Sep 8;5:417. doi: 10.3389/fimmu.2014.00417

Table 1.

Rationale for therapeutic immunization of HIV-infected individuals.

In HIV-infected Drug-Naïve individuals
Delay or block of progression to AIDS or ARV Therapy
In HIV-infected individuals in need of therapy or ARV-treated
  1. cART intensification to:
    • a)
      Accelerate time-to-response to therapy
    • b)
      Block or reduce virus transmission
    • c)
      Help reduce reservoir size in patients given intensive ARV in acute infection
    • d)
      Solve unmet needs of ART (immune activation, immune defects, and proviral DNA)
  2. Drug simplification

  3. Therapy interruption after ARV intensification