Table 2.

HIV/AIDS preventative and therapeutic vaccine … the continuum.

Status	HIV-negative	Asymptomatic	At cART initiation	Upon cART initiation
				Vaccine efficacy Low      →      High
Goal	Prevention of infection	Block of progression (no cART need)	Faster and more efficient response to therapy	cART intensification	cART simplification	cART interruption
		(functional cure, eradication)
Primary (short-term) end-points	HIV test Viral load CD4 counts	CD4 counts Viral load Time to cART initiation	CD4 counts Viral load Time to infection control	CD4 counts Viral load
Secondary (long-term) end-points	None	Proviral DNA (Integrated, non-integrated, total) Neutralization of Tat/Env entry in DCs Markers of immune activation and reconstitution