Table 1.

CLOCK variant association with sleep duration in the Sleep Heart Health Study

		rs11932595						rs12649507*
		Effect Allele	MAF	N	Effect (hours)	StdErr (hours)	P	Effect Allele	MAF	N	Effect (hours)	StdErr (hours)	P
Normalized Sleep Duration	SHHS FHS	G	0.415	2017	− 0.025	0.031	0.421	A	0.312	2016	0.012	0.034	0.712
	SHHS ARIC	G	0.396	1596	0.011	0.025	0.649	A	0.309	1597	0.033	0.026	0.208
	Allebrandt Discovery (14)	G	-	275	0.22	-	0.008	A	-	282	− 0.251	-	0.005
	Allebrandt Replication (14)	G	-	1011	− 0.172	0.086	0.047	A	-	1011	− 0.194	0.097	0.045
	META SHHS†	G	0.407	3613	− 0.003	0.019	0.88	A	0.311	3613	0.025	0.021	0.222
	META SHHS + Allebrandt††	G	-	4899	-	-	0.596	A	-	4906	-	-	0.53
Raw Sleep Duration**	SHHS FHS	G	0.415	1876	− 0.051	0.035	0.144	A	0.312	1875	0.048	0.038	0.202
	SHHS ARIC	G	0.396	1577	0.059	0.039	0.128	A	0.309	1578	0.019	0.04	0.63
	SHHS CHS	G	0.404	798	0.073	0.065	0.262	A	0.316	798	−0.06	0.07	0.391
	META SHHS†	G	0.406	4251	0.008	0.024	0.733	A	0.311	4251	0.022	0.026	0.39
PSG total sleep time**	SHHS FHS	G	0.384	509	− 0.109	0.06	0.067	A	0.325	509	0.047	0.068	0.488
PSG total time in bed**	SHHS FHS	G	0.384	569	− 0.099	0.052	0.055	A	0.325	569	0.107	0.058	0.068

^*rs6843722 used as a proxy for CLOCK SNP rs12649507 in the SHHS FHS, ARIC, and CHS samples (r^2=0.965, D′=1 in 1000 Genomes CEU).

^†Indicates inverse variance weighted Meta-analysis.

^††Indicates sample size weighted Meta-analysis.

^**Analysis adjusted for age, gender, BMI, sleep apnea diagnosis, and 10 principal components of ancestry.