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. Author manuscript; available in PMC: 2014 Sep 8.
Published in final edited form as: Science. 2014 Jan 31;343(6170):506–511. doi: 10.1126/science.1247363

Fig. 4. Functional link between HSP genes and genes of other neurodegenerative conditions.

Fig. 4

(A) Density distribution representing random walk distances of OMIM-derived neurodegeneration gene networks along with 10,000 permutations of randomly selected protein pools compared with the HSP seeds plus candidates pool. The top 5%ile distance is shaded. Only for Parkinson’s, Alzheimer’s, and ALS do the HSP seeds plus candidates fall within this 5%, whereas epilepsy and autism spectrum disorder show no statistical overlap. (B) Bipartite network showing the top links between the set of HSP and ALS proteins. Clear circles, HSP seeds; yellow circles, HSP candidates; boxes, ALS genes (VCP and ALS2 are implicated as causative of both HSP and ALS); line thickness, diffusion similarity between the two proteins.