2a. Cortical Thickness by Group throughout Study
Treatment with PTH increases cortical thickness. Note complete loss of PTH-related cortical thickness increase after PTH discontinuation without followup anti-resorptive treatment. The Aln “holiday” group showed improved cortical thickness.
2b. Cortical Thickness at End of Study
Boxes are as described in Figure 1b. Cortical thinning was observed in OVX rats by the end of study. Except for the Aln “holiday” group, only groups that received both PTH and some combinaton of pre-PTH or post-PTH anti-resorptive treatment had greater cortical thickness than untreated rats at the end of study.