Table 2.
Values at Close of Period 3 (Day 270- End of Experiment)
| Endpoint | Units | Sham (s) |
Veh- Veh-Veh (o) |
Aln- Aln-Aln (a) |
Ral-Ral- Ral (b) |
Aln- Veh-Aln (c) |
PTH- Veh-Veh (d) |
PTH- Aln-Veh (e) |
PTH- Ral-Ral (f) |
Aln- PTH-Veh (g) |
Aln- PTH-Aln (h) |
Ral- PTH-Ral (i) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Central Tibia | ||||||||||||
| Max Load | N | 104.8±23.5 | 92.3±9.5 | 104.8±13.0c | 102.7±8.2c | 119.1±9.1d,f,o | 103.4±11.6c | 110.4±10.5o | 105.9±8.7o | 115.0±6.3o | 115.6±9.0o | 114.8±10.2o |
| Max Stress | N/mm2 | 156.5±36.0 | 137.7±23.4 | 147.2±27.3 | 150.9±16.8 | 154.4±17.5 | 140.1±24.0 | 150.5±34.2 | 140.4±16.9 | 153.5±12.0 | 157.7±23.7 | 164.6±21.6 |
| Work to Failure | kJ/mm2 | 2.13±0.97 | 1.65±0.35 | 2.07±0.84 | 2.35±0.56 | 2.75±0.53d,f,o | 1.82±0.66 | 2.18±0.62 | 2.07±0.35 | 2.42±0.45 | 2.34±0.51 | 2.50±0.49o |
| Ec.Md.Pm/B.Pm | % | 0.66±0.30 | 0.67±0.29 | 0.31±0.16d | 0.64±0.30f | 0.70±0.26f | 0.98±0.42e,f,h | 0.29±0.24 | 0.19±0.14o | 0.56±0.37 | 0.39±0.19 | 0.51±0.50 |
| Ec.Lm.B.Ar | mm2 | - | 0.024±0.029 | - | - | - | 0.034±0.050e,g,h,i | 0.146±0.078o | 0.095±0.062i | 0.161±0.098o | 0.194±0.045o | 0.206±0.094o |
| Lamellar (as % of Ct.Ar) | % | - | 1.01±1.19 | - | - | - | 0.67±0.77e,g,h,i | 4.02±2.01o | 2.64±1.63i | 4.92±3.05o | 5.37±1.10o | 5.42±2.39o |
| Tt.Ar | mm2 | 10.48±0.61 | 10.48±0.50 | 11.18±0.80 | 10.77±0.70 | 11.31±0.64 | 10.89±0.66 | 10.68±0.64 | 10.54±0.40 | 10.89±0.73 | 10.94±0.69 | 10.87±0.99 |
| Ct.Ar | mm2 | 7.00±0.39o | 6.19±0.44 | 7.72±0.32b,d,o | 6.37±0.50e,f,g,h,i | 7.75±0.49d,o | 6.59±0.50g,h,i | 7.65±0.56o | 7.14±0.44h,o | 7.59±0.45o | 8.03±0.52o | 7.75±0.79o |
| Ma.Ar | mm2 | 3.42±0.47o | 3.01±0.38 | 3.19±0.38b,d,e | 4.21±0.36c,f,g,h,i,o | 3.52±0.25d,e | 4.31±0.44f,g,h,i,o | 4.11±0.63f,g,h,i,o | 3.44±0.22 | 3.45±0.49 | 3.36±0.39 | 2.93±0.45 |
| Ct.Th | mm | 0.733±0.048o | 0.648±0.057 | 0.717±0.047 | 0.705±0.024c | 0.779±0.067d,o | 0.662±0.067e,f,h,i | 0.739±0.042o | 0.754±0.048o | 0.744±0.026o | 0.779±0.032o | 0.798±0.048o |
| DBM | 1121±25.7 | 1122±18.6 | 1143±16.5b | 1116±13.1e,f,g,i | 1131±13.8 | 1128±23.9 | 1141±15.9 | 1142±11.0 | 1139±12.0 | 1135±18.3 | 1140±15.2 | |
| Proximal Femur | ||||||||||||
| IDI | 10.29±1.28 | 10.59±1.99 | 9.31±2.41 | 9.43±1.26 | 8.87±2.37 | 10.25±3.10 | 9.88±1.86 | 9.98±1.51 | 8.91±1.75 | 10.56±3.20 | 10.27±2.38 | |
| AED | 29.92±4.59 | 25.96±5.71 | 24.22±4.42 | 22.82±4.06 | 21.30±2.70 | 21.95±4.32 | 20.94±2.87 | 24.98±7.26 | 25.22±3.86 | 26.86±7.66 | 25.23±5.37 | |
| Vertebral Body | ||||||||||||
| Estimated failure load | N | 162±24o | 99±17 | 148±14b,d,e,h,o | 122±16c,d,e,g,h,i | 162±20d,f,h,o | 97±12e,f,g,h,i | 176±15d,f,o | 138±19g,h,o | 163±12h,o | 202±25i,o | 153±19o |
| %Load carried by Ct Bone | % | 47.6±16.1 | 60.4±9.1 | 52.6±9.5 | 45.5±12.9o | 54.3±12.6 | 52.6±12.5 | 40.8±11.6o | 48.4±9.8 | 51.1±7.9 | 51.5±8.6 | 45.5±6.1 |
Mean±SD
Groups are identified by letters a–i and o; superscripts denote differences from groups to right. All groups are labeled “o” when different from Veh-Veh-Veh.
Ec.Lm.B.Ar = Endocortical lamellar bone area
Ec.Md.Pm/B.Pm = Endocortical mineralizing surface
A total of 8 observations were identified as outliers and excluded from the analyses: 1) one from the PTH-Ral-Ral group in the analysis of Ec.MS/BS; 2) one from the PTH-Veh-Veh group in the analysis of Lamellar (as % of Ct.Ar); 3) one from the Aln-Aln-Aln group in the analysis of Ct.Ar; 4) one from the PTH-Aln-Veh group in the analysis of Ct.Th; 5) one from the Aln-Aln-Aln group in the analysis of AED; 6) one from the Ral-PTH-Ral in the analysis of estimated failure load; 7) one from the Aln-Veh-Aln in the analysis of estimated failure load; 8) one from the Aln-Veh-Aln group in the analysis of %Load carried by Ct Bone.