Table 3.

Associations of obesity measures with incident CKD among non-diabetic MESA participants with eGFR > 60 mL/min/1.73m² at baseline.

	/N with incident CKD	Unadjusted rate/year	Incidence rate ratio (95% confidence interval)
			Age-adjusted	Adjusteda
Incident CKD by eGFR creatinine
Body mass index (kg/m2)
<25	147	2.3	1.00 (Reference)	1.00 (Reference)
25.0 – 29.9	194	2.2	0.99 (0.81, 1.20)	0.90 (0.74, 1.10)
30.0 – 34.9	108	2.6	1.30 (1.04, 1.64)	1.06 (0.84, 1.33)
≥35.0	56	2.6	1.44 (1.08, 1.91)	1.18 (0.89, 1.57)
Waist circumference
≤88 (w); ≤102 (m)	276	2.0	1.00 (Reference)	1.00 (Reference)
>88 (w); >102 (m)	229	3.0	1.40 (1.20, 1.64)	1.17 (0.94, 1.46)
Waist to hip ratio
≤0.85 (w); ≤0.9 (m)	109	1.9	1.00 (Reference)	1.00 (Reference)
>0.85 (w); >0.9 (m)	396	2.5	0.97 (0.80, 1.18)	1.02 (0.84, 1.23)
Incident CKD by eGFR cystatin C
Body mass index (kg/m2)
<25	32	0.5	1.00 (Reference)	1.00 (Reference)
25.0 – 29.9	62	0.7	1.48 (0.98, 2.24)	0.95 (0.62, 1.45)
30.0 – 34.9	35	0.9	2.16 (1.35, 3.45)	0.91 (0.56, 1.47)
≥35.0	21	1.0	2.79 (1.63, 4.78)	0.85 (0.48, 1.49)
Waist circumference
≤88 (w); ≤102 (m)	71	0.5	1.00 (Reference)	1.00 (Reference)
>88 (w); >102 (m)	79	1.0	1.88 (1.38, 2.56)	1.28 (0.82, 2.01)
Waist to hip ratio
≤0.85 (w); ≤0.9 (m)	21	0.4	1.00 (Reference)	1.00 (Reference)
>0.85 (w); >0.9 (m)	129	0.8	1.58 (1.01, 2.49)	1.12 (0.71, 1.74)
Incident CKD by eGFR creatinine and eGFR cystatin C
Body mass index (kg/m2)
<25	27	0.4	1.00 (Reference)	1.00 (Reference)
25.0 – 29.9	45	0.5	1.25 (0.78, 1.99)	0.87 (0.53, 1.43)
30.0 – 34.9	30	0.7	2.12 (1.27, 3.55)	1.03 (0.60, 1.76)
≥35.0	12	0.6	1.86 (0.95, 3.65)	0.76 (0.38, 1.52)
Waist circumference
≤88 (w); ≤102 (m)	58	0.4	1.00 (Reference)	1.00 (Reference)
>88 (w); >102 (m)	56	0.7	1.62 (1.14, 2.32)	1.72 (1.07, 2.77)
Waist to hip ratio
≤0.85 (w); ≤0.9 (m)	16	0.3	1.00 (Reference)	1.00 (Reference)
>0.85 (w); >0.9 (m)	98	0.6	1.50 (0.89, 2.53)	1.11 (0.66, 1.88)

^aAdjusted for age, sex, race, baseline eGFR, and hypertension.