Skip to main content
. Author manuscript; available in PMC: 2014 Sep 8.
Published in final edited form as: J Mol Biol. 2012 Feb 24;421(0):364–377. doi: 10.1016/j.jmb.2012.02.026

Figure 6.

Figure 6

Equilibrium model for apoC-II fibril assembly. The model proposes an initial isomerisation of misfolded apoC-II monomers to form an active conformer that self-assembles into fibrils according to an isodesmic self-association process (equation 1). An integral part of the model is fibril breaking and joining coupled to size dependent closed-loop formation. The equilibrium constants for the various steps are shown. The structural model for apoC-II fibrils shows a linear assembly of monomers in a “letter G-like” conformation19.