. Author manuscript; available in PMC: 2014 Sep 8.

Published in final edited form as: J Mol Biol. 2012 Feb 24;421(0):364–377. doi: 10.1016/j.jmb.2012.02.026

Table 3.

Parameters used to fit apoC-II fibril size distributions and the kinetics of fibril formation to an isodesmic self-association model

	Isodesmic self- association model^a	Size-dependent isodesmic self- association model^a	Kinetic model^b
K_eq (M⁻¹) × 10⁻¹¹	3.27059	37.2750^c	3.27
K_i × 10⁶	1.51	0.134	1.5
K_L	1	10	—
k_on (h⁻¹) × 10⁻³	—	—	3
k_e (M⁻¹ h⁻¹) × 10⁻¹²			1.8
k_j (M⁻¹ h⁻¹) × 10⁻⁸	—	—	3.2

Procedures used to fit the size distribution data (Figs. 7 and 8) and kinetic data (Fig. 9) are presented in Materials and Methods. The values of μ and σ (Eq. 1) used to fit the data in Fig. 7 and 8 were 210 and 100, respectively.

The kinetic data on the rate of fibril formation and change in weight-average sedimentation coefficient (Fig. 9) were fitted assuming fixed values for K_eq, and K_i was obtained from the analysis of the size distribution data (Fig. 7). The kinetic data were fitted assuming the absence of closed loops.

The fitted value for K_eq refers to the value obtained for K_eq(2) assuming a size-dependent isodesmic self-association model and was calculated according to Eq. (3). The fitting procedure yielded a fitted value for the exponent “a” of − 0.001.