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. 2014 Sep 8;9(9):e104271. doi: 10.1371/journal.pone.0104271

Figure 2. MAOA expression is induced by chemotherapy in vitro and promotes cell proliferation.

Figure 2

(A) Treatment of LNCaP prostate cancer cells with docetaxel increases MAOA enzyme activity. (B) Over-expression of MAOA increases cell proliferation in PC3 prostate cancer cells. *p<0.05. (C) The irreversible MAOA inhibitor clorgyline reduces MAOA activity in LNCaP cells (*p<0.05). (D) Expression of MAOA in the PC3 prostate cancer cell line (PC3-MAOA) increases cell growth which is inhibited by clorgyline (MAOI). (E) LNCaP cell growth is inhibited by the MAOI clorgyline (*p<0.05).