Table 1. SB431542 suppressed the expression of coding genes regulated by Emdogain.
| Gene ID | Change | Gene Name | ||
| wo/E | wo/ESB43 | |||
| 1. | A_23_P39955 | 17.0 | −1.1 | actin, gamma 2, smooth muscle, enteric |
| 2. | A_33_P3310929 | 11.5 | −1.2 | ADAM metallopeptidase domain 12 |
| 3. | A_23_P14083 | 13.1 | −1.3 | adhesion molecule with Ig-like domain 2 |
| 4. | A_32_P105549 | 10.9 | −1.2 | annexin A8 (and like 1 & 2) |
| 5. | A_33_P3385266 | −10.1 | 1.2 | ATP-binding cassette, sub-family C, member 6 pseudogene |
| 6. | A_23_P125233 | 10.7 | −1.1 | calponin 1, basic, smooth muscle |
| 7. | A_23_P151895 | 41.3 | −1.3 | cartilage intermediate layer protein, nucl. pyrophosphohydrolase |
| 8. | A_23_P121695 | 10.0 | 1.0 | chemokine (C-X-C motif) ligand 13 |
| 9. | A_23_P362191 | −18.5 | −2.1 | chromosome 17 open reading frame 44 & 68 |
| 10. | A_23_P251043 | 12.1 | −1.6 | chromosome 20 open reading frame 39 |
| 11. | A_33_P3423854 | 10.0 | −1.3 | complement component 8, beta polypeptide |
| 12. | A_23_P65518 | 10.2 | −1.8 | dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) |
| 13. | A_23_P46936 | 18.4 | −2.5 | early growth response 2 |
| 14. | A_32_P51237 | 197.3 | −1.1 | KN motif and ankyrin repeat domains 4 |
| 15. | A_33_P3283833 | 13.1 | −1.7 | forkhead box S1 |
| 16. | A_23_P396858 | 17.1 | 1.3 | frizzled homolog 8 (Drosophila) |
| 17. | A_23_P105251 | 18.9 | −2.1 | GLI family zinc finger 1 |
| 18. | A_32_P140489 | 12.8 | 1.0 | growth differentiation factor 6 |
| 19. | A_24_P140608 | 26.3 | −1.1 | heparin-binding EGF-like growth factor |
| 20. | A_33_P3243887 | 15.7 | −1.6 | interleukin 11 |
| 21. | A_33_P3260530 | 32.3 | −1.2 | KN motif and ankyrin repeat domains 4 |
| 22. | A_24_P827037 | 10.4 | −1.4 | leucine rich repeat containing 15 |
| 23. | A_23_P6771 | 26.8 | 1.2 | LIM and cysteine-rich domains 1 |
| 24. | A_33_P3214334 | 12.4 | 1.9 | lymphocyte antigen 6 complex, locus G6F |
| 25. | A_33_P3312676 | 14.0 | −1.3 | myelin transcription factor 1 |
| 26. | A_33_P3246418 | 28.9 | 1.1 | MyoD family inhibitor |
| 27. | A_33_P3224324 | 15.7 | 1.6 | NADPH oxidase 4 |
| 28. | A_23_P138194 | 26.2 | −1.3 | neutrophil cytosolic factor 2 |
| 29. | A_23_P151506 | 22.2 | 2.7 | pleckstrin 2 |
| 30. | A_23_P210581 | 12.6 | −1.2 | potassium voltage-gated channel, subfamily G, member 1 |
| 31. | A_24_P413126 | 14.7 | −2.2 | prostate transmembrane protein, androgen induced 1 |
| 32. | A_33_P3369178 | 27.4 | −2.1 | proteoglycan 4 |
| 33. | A_24_P13041 | 12.9 | 2.5 | rhotekin 2 |
| 34. | A_33_P3299510 | 10.2 | −1.5 | scleraxis homolog A (mouse); scleraxis homolog B (mouse) |
| 35. | A_24_P48204 | −18.2 | 1.1 | secreted and transmembrane 1 |
| 36. | A_23_P106389 | 25.4 | 1.0 | semaphorin 7A, GPI membrane anchor |
| 37. | A_23_P434398 | −10.8 | 1.2 | taxilin beta |
| 38. | A_32_P75264 | −12.0 | −1.6 | transmembrane protein 26 |
| 39. | A_24_P226970 | 17.4 | 1.0 | zinc finger protein 365 |
Palatal fibroblasts were exposed to Emdogain (E) with and without the inhibitor SB431542 (SB43) and a genome-wide microarray was performed. The table shows the genes with a coding sequence that are at least 10-fold changed by Emdogain. SB431542 completely abolished the expression of all Emdogain–regulated genes. The data represent the means of one experiment with cells from three individual donors.