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. 2014 Sep 8;9(9):e104789. doi: 10.1371/journal.pone.0104789

Table 2. Patient characteristics and biopsy outcomes according to glycemic control of DM.

Variables DM− DM+GC DM+PC P-value
No. Patient 1,030 238 100
Mean Age (range) 66.7 (30–91) 66.0 (34–86) 67.8 (47–83) 0.210
Median PSA (ng/ml, range) 7.2 (1.4–3081.0) 6.0 (1.0–412.0) 6.1 (1.2–42.1) 0.207
Median PSAD (ng/ml2, range) 0.18 (0.03–13.32) 0.15 (0.03–1.37) 0.14 (0.04–0.72) 0.037
No. abnormal DRE finding (%) 128 (12.4%) 27 (11.3%) 21 (21.0%) 0.031
Mean prostate volume (ml, range) 45.0 (9–262) 44.5 (14–126) 45.5 (18–151) 0.949
Mean HbA1c (range) - 5.7 (4.4–6.4) 7.4 (6.5–11.3) <0.001
No. overall Pca (%) 301 (29.2%) 48 (20.2%) 44 (44.0%) <0.001
No. high-grade Pca (GS ≥7) (%) 211 (20.5%) 30 (12.6%) 22 (22.0%) 0.016
GS 7 106 (10.3%) 15 (6.3%) 10 (10.0%)
GS 3+4 61 (5.9%) 8 (3.4%) 7 (7.0%)
GS 4+3 45 (4.4%) 7 (2.9%) 3 (3.0%)
GS 8 57 (5.5%) 8 (3.4%) 8 (8..0%)
GS 9 14 (1.4%) 1 (0.4%) 3 (3.0%)
GS 10 11 (1.1%) 1 (0.4%) 0 (0%)

DM, diabetes mellitus, DM−, no DM; DM+GC, DM with good glycemic control, HbA1c <6.5%; DM+PC, DM with poor glycemic control, HbA1c ≥6.5%; PSA, prostate-specific antigen; PSAD, prostate-specific antigen density; DRE, digital rectal examination; Pca, prostate cancer; GS, Gleason Score.