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. 2014 Sep 8;9(9):e106792. doi: 10.1371/journal.pone.0106792

Figure 4. Ashcroft score.

Figure 4

Ashcroft score of wild-type (WT) and S1P3 knockout (KO) mice on the seventh and 28th day after treatment with bleomycin or saline. No significant differences were observed between the Ashcroft scores of KO mice (2.72±0.30) and WT mice (2.96±0.23) on the seventh day after treatment with bleomycin. The Ashcroft scores of KO mice (3.56±0.39) were significantly lower than those of WT mice (5.72±0.68, p = 0.0006, n = 5 in each genotype) on the 28th day. In saline-treated control mice, almost no fibrosis of the lungs was observed on either the seventh day (0.13±0.09 vs. 0.07±0.09 in WT vs. KO mice, respectively; n = 3 in each genotype) or the 28th day (0.17±0.17 vs. 0.07±0.09 in WT vs. KO mice, respectively; n = 3 in each genotype).