Table 2. Stratification analysis of the MDC1 rs4713354A>C genotypes by selected variables in cases and controls.
| Patients (n = 1559) | Controls (n = 1679) | Adjusted OR (95% CI)a | P b | P c | |||
| CA+CC n (%) | AA n (%) | CA+CC n (%) | AA n (%) | CA+CC vs AA | |||
| Age (years) | |||||||
| ≤60 | 245(30.3) | 564(69.7) | 227(25.9) | 650(74.1) | 1.24(1.00–1.54) | 0.387 | 0.338 |
| >60 | 228(30.4) | 522(69.6) | 188(23.4) | 614(76.6) | 1.46(1.16–1.83) | ||
| Sex | |||||||
| Male | 331(30.3) | 760(69.7) | 299(25.2) | 886(74.8) | 1.29(1.07–1.55) | 0.584 | 0.559 |
| Female | 142(30.3) | 326(69.7) | 116(23.5) | 378(76.5) | 1.44(1.08–1.92) | ||
| Smoking status | |||||||
| Ever | 244(29.6) | 580(70.4) | 194(25.4) | 571(74.6) | 1.24(1.00–1.55) | 0.366 | 0.089 |
| Never | 229(31.2) | 506(68.8) | 221(24.2) | 693(75.8) | 1.43(1.14–1.77) | ||
| Pack-years smoked | |||||||
| ≥20 | 175(28.0) | 449(72.0) | 118(24.6) | 361(75.4) | 1.20(0.91–1.57) | 0.564 | 0.339 |
| <20 | 69(34.5) | 131(65.5) | 76(26.6) | 210(73.4) | 1.43(0.97–2.12) | ||
| 0 | 229(31.2) | 506(68.8) | 221(24.2) | 693(75.8) | 1.43(1.14–1.77) | ||
| Drinking status | |||||||
| Ever | 93(31.7) | 200(68.3) | 80(23.4) | 262(76.6) | 1.47(1.02–2.17) | 0.390 | 0.463 |
| Never | 380(30.0) | 886(70.0) | 335(25.1) | 1002(74.9) | 1.29(1.08–1.53) | ||
| Family history of cancer | |||||||
| Yes | 31(24.0) | 98(76.0) | 37(26.1) | 105(73.9) | 0.90(0.51–1.29) | 0.147 | 0.131 |
| No | 442(30.9) | 988(69.1) | 378(24.6) | 1159(75.4) | 1.38(1.17–1.62) | ||
| Histological types | 415(24.7) | 1264(75.3) | |||||
| Adenocarcinoma | 194(31.5) | 421(68.5) | 1.40(1.14–1.72) | 0.831 | |||
| Squamous cell carcinoma | 159(30.2) | 368(69.8) | 1.31(1.06–1.64) | ||||
| Large cell carcinoma | 21(31.8) | 45(68.2) | 1.41(0.83–2.40) | ||||
| Small cell lung cancer | 56(29.0) | 137(71.0) | 1.25(0.90–1.74) | ||||
| Other carcinomas | 38(26.4) | 106(73.6) | 1.08(0.73–1.59) | ||||
| Stages | |||||||
| I | 63(31.5) | 137(68.5) | 415(24.7) | 1264(75.3) | 1.40(1.02–1.93) | 0.683 | |
| II | 39(26.5) | 108(73.5) | 1.09(0.74–1.59) | ||||
| III | 156(31.8) | 334(68.2) | 1.42(1.14–1.77) | ||||
| IV | 215(29.8) | 507(70.2) | 1.29(1.06–1.57) | ||||
a
ORs were adjusted for age, sex, smoking status, drinking status, and family history of cancer.
b
P value of Breslow-Day test.
c
P value of test for the multiplicative interaction.