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. 2014 Sep 8;9(9):e106477. doi: 10.1371/journal.pone.0106477

Figure 4. Schematic of model.

Figure 4

(A) Functional AS sRNAs are generated to some amebic genes when fused to the trigger and the episomal and endogenous genes are silenced. sRNAs and silencing persist after plasmid removal and silencing can be extended to a fusion construct containing a portion of the endogenous gene. (Modified from [29]). (B) Functional AS sRNAs to some amebic RNAi genes are induced when fused to the trigger but the endogenous gene is not silenced. Amebic RNAi sRNAs are not maintained after plasmid removal. (C) No AS sRNAs are made to EhRdRP1, and therefore EhRdRP1 is not silenced.