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. 2014 Sep 8;9(9):e106599. doi: 10.1371/journal.pone.0106599

Table 3. Examples of non-compliance per key criteria from the disease awareness campaigns.

KEY criteria Problem identified Example (CONDITION)
Promotional information Reference to pharmaceutical products to treat a condition or disease in combination with: the name, logo and website of a pharmaceutical company; or a website for a disease awareness campaign; or quick response codes to dedicated websites. “We are an international company with expertise in lung diseases…we develop innovative pharmaceutical solutions…” (Respiratory diseases)
A dedicated website is mentioned in big and bold typeface, as well as the name, logo and website of a pharmaceutical company. (Contraception)
“X strives respond to challenging medical conditions through innovative approaches. Pain treatment is one of our priorities… physical and emotional challenges borne by pain patients are key. Our R&D programme seeks alternative solutions to fight pain.” (Pain)
“Our website helps you to choose the best treatment for your lifestyle. You will be able to find information about all therapies…and also do a test to help you select a suitable treatment.” (Kidney Failure)
“Do you have, or someone close to you has, urinary incontinence? Have a look at our different links: (company) website; your digital logbook for your mobile phone; your online digital logbook to share with your doctor.” (Urinary incontinence)
Misleading or incomplete information No reference is provided on the sources of information provided about prevalence of disease. “One out of every 8 adults in the Netherlands has high cholesterol”. (Cardiovascular diseases)
“One out of each 10 Dutch has asthma …“one out of every 5 Dutch has hay fever”. (Allergies)
“More than 5000 people get post-traumatic dystrophy every year.” (Post-traumatic dystrophy)
“Approximately 40.000 Dutch suffer from renal disease. There are several treatments available for this debilitating disease.” (Kidney Failure)
“One third of those who suffer from migraine in the Netherlands do not get the appropriate treatment…2.5 million Dutch suffer from migraine.” (Migraine)
Use of fear Reference to disability caused by the disease, either through text or picture. An image of a disabled hand is used. (Post-traumatic dystrophy)
“Besides the pain…migraine also has implications for society…it costs the Netherlands 1.7 billion per year… I have seen people who cannot fulfil their dreams…. That is terrible… (Migraine)
Inadequate language Uses medical terminology “Perinasal inflammation…abscesses…metabolic diseases…” (Alarm signals)
Lack of balance More emphasis on the benefits of pharmaceutical treatment than risks. Symptoms are accentuated by layout and/or enumeration. Risk factors are portrayed as diseases. Treatment is accentuated. “This disease can have a great impact on the individual and its environment. It disturbs your daily life. It is important to diagnose it at an earlier stage, so that treatment can begin quickly. Therapy includes anti-inflammatory drugs and painkillers.” (Post-traumatic dystrophy)
“These symptoms can seem mild, but they can have a great impact on your daily life, at school or at work, and even disturb your sleep patterns”.
“Symptoms such as shortness of breath, cough and wheeziness result in an asthma attack…Red and itchy eyes, running nose, stuffy nose, sneezes and tiredness can have serious implications.” Allergies)
Symptoms are referred to in headings in big and bold typeface. (Allergies) (Alarm signals) (Urinary incontinence)
“…when you have high cholesterol, you have a higher risk of developing cardiovascular diseases… you can reduce that risk by…treating your high cholesterol levels. Have a look at our new website about healthy living with lower cholesterol”. (Cardiovascular diseases)
“Now women are able to choose a pill that contains a natural hormone and a progestogen. This natural hormone is easily absorbed by the body…this pill has a neutral effect on acne, weight-gain and blood pressure…your periods will be shorter and lighter…” (Contraception)
Contraception is mentioned on six occasions in big and bold typeface. (Contraception)
The sentence: “I (do not) want a pill” and the address of a dedicated website are included in big and bold typefaces. (Contraception)
“…suffering from migraine, days in a row, a pain impossible to bear…with nausea, and sensitivity to light and noises…seek a good treatment…Medicines play an important role…we advise patients to try two different triptans…” (Migraine)
Use of testimonials Specialist mentions treatment and specific drug classes “The doctor can prescribe anti-histamines…or corticosteroids… immunotherapy can be considered an option”. (Allergies)
A comparison is made of the patient's experience before and after treatment with a specific drug. “I had tummy and back aches with another pill. I visited my doctor and together we have chosen a new pill with a different ingredient. That has helped”. “ The first pill I took caused weight-gain and emotional changes. My GP then prescribed a lighter pill and I am feeling fine”. (Contraception)
Absence of author and/or sponsor No author and/or sponsor identified. (Allergies), (Alarm signals), (Cardiovascular diseases), (Contraception), (Migraine)