Table 2. The neutralizing antibody responses after EV71vac immunization.
| Group | Nt titers (GMT)# | |||||||
| Pre-immune (0 week) | After 1st vaccination$ (3 weeks) | After 2nd vaccination (6 weeks) | After 3rd vaccination (9 weeks) | 12 weeks | 26 weeks | 39 weeks | 56 weeks | |
| High dose | <8 | 140±123 | 1737±1187 | 4084±1697** | 1446±1188 | 1126±504 | 800±581 | 451±122 |
| Low dose | <8 | 154±73 | 1378±315 | 5054±1404** | 1640±494 | 290±140 | 263±140 | 106±81 |
| PBS | <8 | <8 | <8 | <8 | <8 | <8 | <8 | <8 |
#
The neutralization titer (Nt) was assayed with EV71/E59 (B4 subgenotype) and the GMT ± SE was shown.
$
Three groups were immunized three times with 10 µg (high dose; n = 4) or 5 µg (low dose; n = 4) of EV71vac vaccine or PBS (n = 2) formulated with alum.
**There is a significant difference compared to PBS control group (p<0.01 by Two-way ANOVA test).