Table 3. The cross-neutralization pattern of immunized monkey sera after EV71vac (B4 subgenotype) vaccination.
| Virus strain | Subgenotype | After 2nd Vaccination (6 weeks)$ | 26 weeks | 56 weeks | |||
| High dose | Low dose | High dose | Low dose | High dose | Low dose | ||
| EV71-E59 | B4 | 1737±1187# | 1378±315 | 1126±504 | 290±140 | 451±122 | 106±81 |
| EV71-0204 | B1 | 562±65 | 200±95 | 71±8 | 35±4 | 56±6 | 28±3 |
| EV71-0692 | B5 | 2021±26 | 1842±147 | 750±43 | 126±29 | 562±65 | 119±49 |
| EV71-0448 | B5 | 1059±438 | 944±275 | 422±73 | 127±44 | 316±36 | 100±23 |
| EV71-5746 | C2 | <8 | <8 | <8 | <8 | <8 | <8 |
| EV71-4643 | C2 | 1122±682 | 1227±31 | 841±146 | 668±38 | 668±39 | 473±138 |
| EV71-C4D | C4A | 1625±379 | 202±99 | 596±103 | 56±34 | 398±190 | 40±30 |
| EV71-1757 | C4A | 447±272 | 246±112 | 422±228 | 42±29 | 237±128 | 30±9 |
| EV71-N3340 | C4B | <8 | <8 | <8 | <8 | <8 | <8 |
| CVA16-5079N | CVA16 | <8 | <8 | <8 | <8 | <8 | <8 |
#
The neutralization titer was assayed with various enteroviruses indicated in the left and the GMT ± SE was presented.
$
Three groups were immunized three times with 10 µg (high dose; n = 4) or 5 µg (low dose; n = 4) of EV71vac vaccine formulated with alum. The PBS control (n = 2) did not show any neutralization activity (<8) to all enteroviruses.