. 2014 Sep 8;9(9):e106756. doi: 10.1371/journal.pone.0106756

Table 4. The neutralizing antibody responses after EV71vac booster one-year later.

EV71vac vaccinated Group	Nt titers (GMT)^#
	Pre-booster (56 weeks)	Booster^$	After 1^st booster (56+3 weeks)	After 2^nd booster (56+6 weeks)
High dose (10 µg)	451±122	EV71vac (5 µg/dose)	1090±137^*	1413±67^*
Low dose (5 µg)	106±81	EV71vac (5 µg/dose)	661±101	827±121
PBS	<8	PBS	<8	<8

The neutralization titer (Nt) was assayed with EV71/E59 (B4 subgenotype) and the GMT ± SE was shown.

Three groups were boosted two times at week 56 and 59 with 5 µg of EV71vac vaccine for both high dose (n = 4) and low dose (n = 4) group or with PBS formulated with alum (n = 2).

*There is a significant difference compared to low dose group (p<0.05 by Two-way ANOVA test).