Table 1. A. fumigatus proteins, involved in secondary metabolism, and identified by shotgun mass spectrometry.

Cluster Noa	CADRE ID. (AFUA_)	Protein name	Chromosome No	LaeA regulationa	Product(s)
1	1G10350	Phosphoglycerate kinase PgkA (EC 2.7.2.3)	1	Yes	Fumigaclavine C
7	3G03280	FAD binding monooxygenase	3	No	Putatively two products: a siderophore and a toxin
7	3G03330	Mitochondrial enoyl reductase	3	No
10	3G14680	Lysophospholipase 3 (EC 3.1.1.5) (Phospholipase B 3)	3	Partial	Unknown
13	4G14380	Glutathione S-transferase, putative	4	Partial	Unknown
18	6G09740	GliT (Thioredoxin reductase GliT) (EC 1.-.-.-)	6	Yes	Gliotoxin
22	8G00230	Phytanoyl-CoA dioxygenase family protein	8	Yes	‘Supercluster’ producing Fumitremorgin B, Pseurotin A and Fumagillin
22	8G00370	Polyketide synthase, putative	8	Yes
22	8G00380	DltD N-terminal domain protein	8	Yes
22	8G00390	O-methyltransferase, putative	8	Yes
22	8G00400	Unknown function protein	8	Yes
22	8G00430	Unknown function protein	8	Yes
22	8G00440	Steroid monooxygenase, putative (EC 1.-.-.-)	8	Yes
22	8G00480	Phytanoyl-CoA dioxygenase family protein	8	Yes
22	8G00500	Acetate-CoA ligase, putative (EC 6.2.1.1)	8	Yes
22	8G00510	Cytochrome P450 oxidoreductase OrdA-like, putative	8	Yes	‘Supercluster’ producing Fumitremorgin B, Pseurotin A and Fumagillin
22	8G00530	Alpha/beta hydrolase, putative	8	Yes
22	8G00540	Hybrid PKS-NRPS enzyme, putative	8	Yes
22	8G00550	Methyltransferase SirN-like, putative	8	Yes
22	8G00580	Glutathione S-transferase, putative	8	Yes

CADRE ID., A. fumigatus gene annotation nomenclature according to [1] and [71].

^aCluster numbers and LaeA regulation as denoted in [38].