FIGURE 7.

Type 1 IFN signaling represses granuloma formation. All mice were infected with 200 H. polygyrus third stage larvae. (A) Adult H. polygyrus numbers recovered from the intestinal tract of C57BL/6 and IFNAR1^−/− mice 28 d post infection; data shown are representative of two experiments, each with five to six mice per group. (B) H. polygyrus eggs per gram of feces taken 14 and 28 d post infection in C57BL/6 and IFNAR1^−/− mice; data shown are representative of two experiments, each with five to six mice per group. (C) Number of granulomas formed along the small intestinal tract 28 d following H. polygyrus infection. Data shown are pooled from two experiments, each with two to six mice per group. **p ≤ 0.01, ***p ≤ 0.001.