Figure 5. Adaptive immune responses are IL-1 dependent but Caspase-1 independent.
Groups of four mice were either sham vaccinated with PBS or vaccinated with heat-killed B. pertussis (wP) by administering 200 µL i.p. at 28 and 14 days prior to challenge inoculation with 5×105 CFU. Lungs were excised at seven days post-challenge and to determine bacterial CFUs. Bar graphs represent the mean CFU per lung ± standard deviation. Significance was determined by one-way ANOVA and Tukey’s multiple comparison post-hoc test with *p<0.05, ***p<0.001. Data is representative of two independent experiments.