Table 2. Association analyses between SERPINA6-rs1998056 and HCC risk in different genetic models.

Geneticmodels	Overall				Male				Female
	Cases/Controls	Crude OR(95%CI)	Adjusted OR(95%CI)*	P *	Cases/Controls	Crude OR(95%CI)	Adjusted OR(95%CI)†	P †	Cases/Controls	Crude OR(95%CI)	Adjusted OR(95%CI)†	P †
Genotype	1,072/1,997			0.765	857/1,601			0.504	215/396			0.015
CC	280/538	Reference	Reference		229/405	Reference	Reference		51/133	Reference	Reference
CG	551/998	1.06(0.89, 1.27)	1.07(0.89, 1.29)	0.679	448/815	0.97(0.78, 1.19)	1.00(0.81, 1.23)	0.994	103/183	1.47 (0.98, 2.20)	1.41 (0.93, 2.14)	0.109
GG	241/461	1.00(0.81, 1.24)	1.05(0.84, 1.30)	0.917	180/381	0.84(0.66, 1.06)	0.89(0.69, 1.13)	0.329	61/80	1.99 (1.25, 3.16)	2.03 (1.26, 3.27)	0.004
Additive	1,072/1,997			0.655	857/1,601			0.344	215/396			0.004
CC	280/538	Reference	Reference		229/405	Reference	Reference		51/133	Reference	Reference
CG	551/998	1.00(0.90, 1.12)	1.03(0.92, 1.14)		448/815	0.92(0.81, 1.03)	0.94(0.83, 1.07)		103/183	1.41 (1.12, 1.78)	1.42 (1.12, 1.81)
GG	241/461				180/381				61/80
Recessive	1,072/1,997			0.987	857/1,601			0.242	215/396			0.015
CC+CG	831/1,536	Reference	Reference		677/1,220	Reference	Reference		154/316	Reference	Reference
GG	241/461	0.97(0.81, 1.15)	1.00(0.84, 1.20)		180/381	0.85(0.70, 1.04)	0.89 (0.72, 1.09)		61/80	1.57 (1.07, 2.30)	1.64 (1.10, 2.43)
Dominant	1,072/1,997			0.486	857/1,601			0.706	215/396			0.019
CC	280/538	Reference	Reference		229/405	Reference	Reference		51/133	Reference	Reference
CG+GG	792/1,459	1.04(0.88, 1.23)	1.06(0.89, 1.27)		628/1,196	0.93(0.77, 1.12)	0.96 (0.79, 1.17)		164/263	1.63 (1.12, 2.37)	1.60 (1.08, 2.36)

*Adjusted for age, gender, smoking and drinking status.

^†Adjusted for age, smoking and drinking status.

Significant results were highlighted in bold.